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KMID : 1059520140580030277
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Journal of the Korean Chemical Society
2014 Volume.58 No. 3 p.277 ~ p.282
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Measurement of Optical Purity for Commercially Avialable Dexibuprofen and Ibuprofen Sold in 2013
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Ryoo Sang-Hyun
Lee Sang-Heon
Seo Hae-Chan
Song Jung-Suk
Ryoo Dong-Hyun
Yu Jeong-Jae
Kim Hyun-Young
Lee Jae-Hwan
Ryoo Jae-Jeong
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Abstract
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The optical purity of 11 commercial dexibuprofens and 7 ibuprofens sold in Korea in 2013 were examined by chiral HPLC. The Chiralcel OD-H column and LUX-Cellulose-1 column were used as chiral stationary phases and the mixed eluent of hexane:isopropanol:acetic acid as 100:1:0.1 was used as a mobile phase with a flow rate of 1.0 mL/min. Each data was obtained from an average value of at least three different experiments for each sample and the average value of relative standard deviation of them appeared very small, 0.19%. Average optical purity value (97.5%) of eleven commercial dexibuprofens used in this study were smaller than those of 9 years ago (99.2%), but larger than four years ago (95.6%). Enantiomeric ratios of (R)- and (S)- isomers of seven ibuprofen samples used in this experiment were achieved at about 50:50 which was different with the result (44:56) from four years ago.
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KEYWORD
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Chiral chromatography, Optical purity, Commerical dexibuprofen
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